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The Link between Ankylosing Spondylitis, Crohnâs Disease, Klebsiella, and Starch Consumption 872632.pdf
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Spondyloarthritis (SpA) is a chronic inflammatory disease affecting both the peripheral and the axial skeleton. Axial spondyloarthritis (axSpA) encompasses both the radiographic (r-axSpA) and the non-radiographic (nr-axSpA) forms of the disease^[https://www.nature.com/articles/s41598-024-52016-4]
Thus, grains, lipid-rich foods, total fats and starch were associated with a lower constipation score, while sugary products, sodium, and higher energy intake were correlated with higher constipation.^[https://doi.org/10.3390%2Fnu14010122]
If patients have the combination of both HLA-B27 and a leaky gut, then their chances of developing axial arthritis are very high: In a small study my coauthors and I conducted, magnetic resonance imaging scans showed abnormalities in the sacroiliac joints in every single person who had both HLA-B27 and a diagnosis of CD. In summary, the development of arthritis is probably the result of both a genetic predisposition and exposure to luminal bacteria, but direct mechanistic evidence to support this hypothesis is not yet available.^[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424429/]
Verschillende studies over voeding hebben aangetoond dat de voornaamste voedingsbodem voor bacteriĂ«le groei in de darmen wordt gevormd door een dieet met zetmeel. Daarom zou een simpele methode om de Klebsiellabacterie in de darm terug te dringen zijn, het verminderen van de inname van zetmeel met het eten en de SpondylitispatiĂ«nt dus te vragen om voedsel te eten met minder zetmeel erin. Het âLonden A(nkylosing)S(pondylitis) dieetâ bestaat uit een drastische vermindering van zetmeelconsumptie en het compenseren van het caloriegebrek met meer groente en proteĂŻnen. Het voornaamste principe of mantra van het Londen AS dieet is: gĂ©Ă©n brood, gĂ©Ă©n aardappels, gĂ©Ă©n gebak en gĂ©Ă©n pasta.AlmondFigtree.pdf
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Sorry for writing a book I just learned some stuff and wanted to share it. Please feel free to let me know if you see any errors with what I wrote. Also I kind of wanted to do this for myself so I could explain it to my family and friends easier. I tried to break it down into sections to make it easier to read.
The Science behind AS:
Ankylosing Spondylitis or AS is caused by a bacteria caused Klebsiella pneumoniae which is closely related to cells in our body. More specifically they mimic a gene called HLA-B27. As the immune system attempts to destroy the klabsiella, it also destroys the B27 cells causing the inflammatory progress of AS. The two major areas AS causeâs problems are the joints and the gut.
The thing that I find kind of strange is people that are HLA-B27 negative (like me) are also seeing successful results of the Low/No Starch Diet and Iâm not the only one. Trust me Iâm not complaining though. I think the reason Iâm HLA-B27 negative is because I have Ulcerative Colitis which is a type of IBD. Their are only 2 types of IBD, Crohns and Ulcerative Colitis and I guess for some reason Carol said people with Crohns and AS are more likely to be HLA-B27 negative. Iâm thinking that maybe since I have the only other type of IBD that maybe thatâs why Iâm HLA-B27 negative but who knows. Iâve also been told that some people find out they are negative just to find out with another test they are positive. If they let your blood sit too long before they test it they can get a false negative. Also the reason they tell you to get this checked is because people with this gene react better to this diet. Basically I donât really care as long as this diet works for me which it seems to be working already and Iâm only on day 9 of the diet today.
How the Low Starch (No Starch) Diet was discovered: Basically the Low Starch Diet was discovered by luck by Carol Sinclair and Professor Alan Ebringer (separately). The way Carol discovered it was she was diagnosed with IBS and started actually adding more starchy foods as recommended by her doctor which made things worse. Then she said in 1986 she was âat my witsâ endâ and she decided to try eliminating wheat from her diet after watching a TV documentary about food allergies with wheat. She saw results right away. After testing all different foods she found out it was actually starch that caused her problems and if she eliminated it she could keep her IBS under control. Later Carol found out she also has AS and tested positive for HLA-B27 (a marker in your blood that most AS patients have except most of them with Crohnâs disease and AS which for some reason test negative for HLA-B27). Professor Alan Ebringer who is a Professor in Immunology and also specializes in the field of rheumatology figured out that a bacteria called Klebsiella pneumoniae was the cause of AS which in turn caused other problems like IBS, IBD, Iritis etc. The thing the professor couldnât figure out was how to treat patients infected with these bacteria. One day one of his AS patients asked him to devise a weight-loss diet. The professor recommended that he eat as much steak and as many tomatoes as he wanted, and drink a bottle of red wine daily. His patient did this and told the professor not only did he lose weight but his joint and back pains went away. After hearing this, the professor came to the conclusion that the bacteria must live on the undigested starch in the gut and eliminating starch from the diet must have starved them. Further research confirmed the bacteria did in fact live in the gut and grow on remnants of the starch in our diet. That professor is a smart guy. He put his patients on a low-starch diet and his patients reported amazing relief from symptoms. ^[https://kickas.org/ubbthreads/ubbthreads.php/topics/205870/3]
First big flare was 7 years ago - took 9 months to even guess at what it was, but then it went into remission. It slowly started to creep back over the last few years, until this winter it got out of control and I was starting to lose functionality. Everything became very difficult, whether getting out of bed, a chair, a car⊠Even breathing hurt sometimes. I spent months reading everything I could about AS and the treatments that people have used. I tried all kinds of stuff to no avail, but was aware that the NSD should do some good. Initially I went on NSD with little success because it turned out I was popping all kinds of starchy supplements and didnât know it! Later I doscovered that things like beef and eggs, which I was allergic too as a child, also seemed to set of the AS monster, at least in a mild way. Sooo- 6 months NSD later, with no eggs or beef, very little dairy other than butter, and I am almost pain free!
I have lost weight and am more active than before and honestly feel better physically than before the diet began.
I no longer take any pills at ALL for AS - it was tough but I finally got off NSAIDS which really seem to make the disease worse, IMHO.
I feel lucky to have found this site and the people on it - I have my life back in a big way and I plan on kicking AS for a long time to come. It still lingers in the wings, waiting to bite me if I stray from the diet but I know what to do now.
One piece of advice I can give to people trying the NSD: Be very very strict about it. It may not work at all unless you do - sometimes even small things like spices (most of which are starchy) and garlic can set you off and then it will seem like NSD does you no good. It sounds nuts, but I would suggest trying something like nothing but bacon and eggs(no pepper!) for 2 weeksâŠAnd cut out everything else, even supplements! Just drink water. You will get used to the lack of carbs after a few days and it will be a much more fair test of how food affects the AS. (it will also be easy to plan, and even though it seems like its unhealthy, a few weeks wont hurt you) - its important to have some success in the beginning so you will know you are on the right track. Then you can add more to your diet and you will know how to get back on track if something goes wrong.
Go out and kick some! ^[https://kickas.org/ubbthreads/ubbthreads.php/topics/205870/5]
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Links
https://kickas.org/ubbthreads/ubbthreads.php/topics/205870/21/no-low-starch-diet-success-stories
Zetmeelhoudende groentes
